Substrate
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Generation 1
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Generation 2
XenoSite
Tolfenamic acid
Cc1c(Cl)cccc1Nc1ccccc1C(=O)O
CHEBI
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Description
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Phase 1
Reactivity
Epoxidation
Quinonation
N-Dealkylation
UGT Conjugation
i
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stable oxygenation
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unstable oxygenation
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dehydrogenation
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reduction
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hydrolysis
Generation 1
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N-(2-methyl-3-chloro-4-hydroxyphenyl)anthranilic acid
Cc1c(Nc2ccccc2C(=O)O)ccc(O)c1Cl
CHEBI
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Phase 1
Reactivity
Epoxidation
Quinonation
N-Dealkylation
UGT Conjugation
i
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Generation 2
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CC12OC1(Cl)C(O)=CC=C2Nc1ccccc1C(=O)O
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Phase 1
Reactivity
Epoxidation
Quinonation
N-Dealkylation
UGT Conjugation
i
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Generation 3
Select a metabolite to form the next generation.
quinone formation
Probability 0.11
0.11
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quinone formation
Probability 0.11
0.11
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quinone formation
Probability 0.11
0.11
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Benzoic acid
quinone formation
Probability 0.04
0.04
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quinone formation
Probability 0.00
0.00
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Showing 5 of 13 metabolites
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