Nalidixic acid

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Nalidixic acid Epoxidation prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CCN1c2nc(C)ccc2C(=O)C2(C(=O)O)OC12 N-Dealkylation prediction

Generation 2

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CCNc1nc(C)ccc1C(=O)C1(C(=O)O)OC1O UGT Conjugation prediction

Generation 3

glucuronidation · 0.13

*OC1OC1(C(=O)O)C(=O)c1ccc(C)nc1NCC |$GlcA;;;;;;;;;;;;;;;;;;;$|