Amp morpholidate

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Amp morpholidate Epoxidation prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Nc1ncnc2c1N1OC1N2C1OC(COP(=O)(O)N2CCOCC2)C(O)C1O N-Dealkylation prediction

Generation 2

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Nc1ncnc(NC2OC(COP(=O)(O)N3CCOCC3)C(O)C2O)c1N1OC1O UGT Conjugation prediction

Generation 3

Select a metabolite to form the next generation.