Substrate
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Generation 1
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Generation 2
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Generation 3
XenoSite
Astemizole
COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1
CHEBI
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Description
▾
Phase 1
Reactivity
Epoxidation
Quinonation
N-Dealkylation
UGT Conjugation
i
About this model
Generation 1
Show metabolites
COc1ccc(CCN2CCC(Nc3nc4ccccc4n3C=C3C=CC(=O)C=C3)CC2)cc1
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Phase 1
Reactivity
Epoxidation
Quinonation
N-Dealkylation
UGT Conjugation
i
About this model
Generation 2
Show metabolites
COc1ccc(CCN2CCC(Nc3nc4c(n3C=C3C=CC(=O)C=C3)=CC3OC3C=4)CC2)cc1
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Phase 1
Reactivity
Epoxidation
Quinonation
N-Dealkylation
UGT Conjugation
i
About this model
Generation 3
Show metabolites
COc1ccc(CCNCCC(CC(=O)O)Nc2nc3c(n2C=C2C=CC(=O)C=C2)=CC2OC2C=3)cc1
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dealkylation · 0.67
Phase 1
Reactivity
Epoxidation
Quinonation
N-Dealkylation
UGT Conjugation
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