Arenamide a

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Arenamide a Quinonation prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CCCCCCC(C)C1CC(=O)NCC(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CC2=CC=CC(=O)C2=O)C(=O)O1 N-Dealkylation prediction

Generation 2

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CCCCCCC(C)C(CC(=O)NCC(=O)NC(C(=O)NC(CC(C)C)C(N)=O)C(C)C)OC(=O)C(CC1=CC=CC(=O)C1=O)NC(=O)C(C)=O gsh prediction

CCCCCCC(C)C(CC(=O)NCC(=O)NC(C(=O)NC(CC(C)C)C(N)=O)C(C)C)OC(=O)C(CC1=CC=CC(=O)C1=O)NC(=O)C(C)=O protein prediction

CCCCCCC(C)C(CC(=O)NCC(=O)NC(C(=O)NC(CC(C)C)C(N)=O)C(C)C)OC(=O)C(CC1=CC=CC(=O)C1=O)NC(=O)C(C)=O cyanide prediction

CCCCCCC(C)C(CC(=O)NCC(=O)NC(C(=O)NC(CC(C)C)C(N)=O)C(C)C)OC(=O)C(CC1=CC=CC(=O)C1=O)NC(=O)C(C)=O dna prediction

Generation 3

glutathionation · 0.02

*C1C=C(O)C(=O)C(CC(NC(=O)C(C)=O)C(=O)OC(CC(=O)NCC(=O)NC(C(=O)NC(CC(C)C)C(N)=O)C(C)C)C(C)CCCCCC)=C1 |$GSH;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$|