Tenofovir

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Tenofovir Quinonation prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CC(C[N+]1=c2ncnc(N)c2=NC1=O)OCP(=O)(O)O stable oxygenation prediction

CC(C[N+]1=c2ncnc(N)c2=NC1=O)OCP(=O)(O)O unstable oxygenation prediction

CC(C[N+]1=c2ncnc(N)c2=NC1=O)OCP(=O)(O)O dehydrogenation prediction

CC(C[N+]1=c2ncnc(N)c2=NC1=O)OCP(=O)(O)O reduction prediction

CC(C[N+]1=c2ncnc(N)c2=NC1=O)OCP(=O)(O)O hydrolysis prediction

Generation 2

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CC(O)C[N+]1=c2ncnc(N)c2=NC1=O Epoxidation prediction

Generation 3

epoxidation · 0.00

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CC(O)CN1C(=O)N=C2C1=NC=NC21NO1