Tenofovir

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Tenofovir Quinonation prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CC(C[N+]1=c2ncnc(N)c2=NC1=O)OCP(=O)(O)O N-Dealkylation prediction

Generation 2

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CC(OCP(=O)(O)O)C(=O)O UGT Conjugation prediction

Generation 3

glucuronidation · 0.99

*OC(=O)C(C)OCP(=O)(O)O |$GlcA;;;;;;;;;;;$|