Anagrelide

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Anagrelide Quinonation prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

O=C1Cn2cc3c(=O)c(Cl)ccc-3nc2N1 N-Dealkylation prediction

Generation 2

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

O=C1CNC=C2C(=O)C(Cl)=CC=C2N=C(O)N1 gsh prediction

O=C1CNC=C2C(=O)C(Cl)=CC=C2N=C(O)N1 protein prediction

O=C1CNC=C2C(=O)C(Cl)=CC=C2N=C(O)N1 cyanide prediction

O=C1CNC=C2C(=O)C(Cl)=CC=C2N=C(O)N1 dna prediction

Generation 3

glutathionation · 0.25

*C1C=C2N=C(O)NC(=O)CNC=C2C(O)=C1Cl |$GSH;;;;;;;;;;;;;;;;;$|