Anagrelide

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Anagrelide Quinonation prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

O=C1Cn2cc3c(=O)c(Cl)ccc-3nc2N1 N-Dealkylation prediction

Generation 2

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

O=C(O)C(=O)Nc1nc2ccc(Cl)c(=O)c-2c[nH]1 UGT Conjugation prediction

Generation 3

glucuronidation · 0.98

*OC(=O)C(=O)Nc1nc2ccc(Cl)c(=O)c-2c[nH]1 |$GlcA;;;;;;;;;;;;;;;;;;$|