Amperozide cation

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Amperozide cation Quinonation prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CCNC(=O)N1CC[NH+](CCCC(=C2C=CC(F)=CC2=O)c2ccc(F)cc2)CC1 stable oxygenation prediction

CCNC(=O)N1CC[NH+](CCCC(=C2C=CC(F)=CC2=O)c2ccc(F)cc2)CC1 unstable oxygenation prediction

CCNC(=O)N1CC[NH+](CCCC(=C2C=CC(F)=CC2=O)c2ccc(F)cc2)CC1 dehydrogenation prediction

CCNC(=O)N1CC[NH+](CCCC(=C2C=CC(F)=CC2=O)c2ccc(F)cc2)CC1 reduction prediction

CCNC(=O)N1CC[NH+](CCCC(=C2C=CC(F)=CC2=O)c2ccc(F)cc2)CC1 hydrolysis prediction

Generation 2

(11c)acetic acid

dealkylation · 0.34

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

(11c)acetic acid