Aclacinomycin t

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Aclacinomycin t Quinonation prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CCC1(O)CC(OC2CC(N(C)C)C(O)C(C)O2)c2c(cc3c(=O)c4c(=O)ccc(=O)c=4c(=O)c3c2O)C1C(=O)OC UGT Conjugation prediction

Generation 2

glucuronidation · 0.09

*OC1C(C)OC(OC2CC(O)(CC)C(C(=O)OC)c3cc4c(=O)c5c(=O)ccc(=O)c=5c(=O)c4c(O)c32)CC1N(C)C |$GlcA;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$|