Substrate
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Generation 1
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Generation 2
XenoSite
Imipramine
CN(C)CCCN1c2ccccc2CCc2ccccc21
CHEBI
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Description
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Phase 1
Reactivity
Epoxidation
Quinonation
N-Dealkylation
UGT Conjugation
i
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stable oxygenation
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unstable oxygenation
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dehydrogenation
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reduction
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hydrolysis
Generation 1
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Desipramine
CNCCCN1c2ccccc2CCc2ccccc21
CHEBI
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Description
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Phase 1
Reactivity
Epoxidation
Quinonation
N-Dealkylation
UGT Conjugation
i
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Generation 2
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3-(methylamino)propanoic acid
CNCCC(=O)O
CHEBI
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Description
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n dealkylation · 0.12
Phase 1
Reactivity
Epoxidation
Quinonation
N-Dealkylation
UGT Conjugation
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