Arverapamil

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Arverapamil stable oxygenation prediction

Arverapamil unstable oxygenation prediction

Arverapamil dehydrogenation prediction

Arverapamil reduction prediction

Arverapamil hydrolysis prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

COc1cc(CCNCCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)ccc1O Epoxidation prediction

Generation 2

epoxidation · 0.01

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

COc1ccc(C(C#N)(CCCNCCC2=CC=C(O)C3(OC)OC23)C(C)C)cc1OC