Aristada

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Aristada stable oxygenation prediction

Aristada unstable oxygenation prediction

Aristada dehydrogenation prediction

Aristada reduction prediction

Aristada hydrolysis prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CCCCCCCCCCCC(=O)OCN1C(=O)CCc2ccc(OCCCCO)cc21 UGT Conjugation prediction

Generation 2

glucuronidation · 1.00

*OCCCCOc1ccc2c(c1)N(COC(=O)CCCCCCCCCCC)C(=O)CC2 |$GlcA;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$|