Amp morpholidate

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Amp morpholidate stable oxygenation prediction

Amp morpholidate unstable oxygenation prediction

Amp morpholidate dehydrogenation prediction

Amp morpholidate reduction prediction

Amp morpholidate hydrolysis prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Nc1ncnc2c1ncn2C1OC(COP(=O)(O)NCCOCC=O)C(O)C1O N-Dealkylation prediction

Generation 2

Adenosine 5'-phosphoramidate

dealkylation · 0.24

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Adenosine 5'-phosphoramidate