Substrate
Generation 1

Amlodipine

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Amlodipine stable oxygenation prediction

Amlodipine unstable oxygenation prediction

Amlodipine dehydrogenation prediction

Amlodipine reduction prediction

Amlodipine hydrolysis prediction

Generation 1

hydrolysis · 0.36

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)O)C1c1ccccc1Cl