Azabenzimidazole

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Azabenzimidazole N-Dealkylation prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

N=C1N=CNC1=CC=CO Epoxidation prediction

Generation 2

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

N=C1N=CNC1=CC1OC1O stable oxygenation prediction

N=C1N=CNC1=CC1OC1O unstable oxygenation prediction

N=C1N=CNC1=CC1OC1O dehydrogenation prediction

N=C1N=CNC1=CC1OC1O reduction prediction

N=C1N=CNC1=CC1OC1O hydrolysis prediction

Generation 3

epoxidation · 0.41

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

N=C1C(=CC2OC2O)NC2ON12