Aclacinomycin s

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Aclacinomycin s N-Dealkylation prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CCC1(O)CC(OC2CC(=O)C(OC3CC(O)C(O)C(C)O3)C(C)O2)c2c(cc3c(c2[O-])C(=O)c2c(O)cccc2C3=O)C1C(=O)OC UGT Conjugation prediction

Generation 2

glucuronidation · 0.15

*OC1CC(OC2C(=O)CC(OC3CC(O)(CC)C(C(=O)OC)c4cc5c(c([O-])c43)C(=O)c3c(O)cccc3C5=O)OC2C)OC(C)C1O |$GlcA;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$|