Azilsartan medoxomil anion

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

Azilsartan medoxomil anion Epoxidation prediction

Generation 1

Phase 1 Reactivity Epoxidation Quinonation N-Dealkylation UGT Conjugation

CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(C2=CC3OC3C=C2c2noc(=O)[n-]2)cc1 gsh prediction

CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(C2=CC3OC3C=C2c2noc(=O)[n-]2)cc1 protein prediction

CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(C2=CC3OC3C=C2c2noc(=O)[n-]2)cc1 cyanide prediction

CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(C2=CC3OC3C=C2c2noc(=O)[n-]2)cc1 dna prediction

Generation 2

glutathionation · 0.12

*C1C=C(c2ccc(Cn3c(OCC)nc4cccc(C(=O)OCc5oc(=O)oc5C)c43)cc2)C(c2noc(=O)[n-]2)=CC1O |$GSH;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$|